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Fecal Calprotectin Levels Significantly Correlate with Polyp Size in Children and Adolescents with Juvenile
Yu Bin Kim1, Ju Young Kim2, Sujin Choi3
1Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
Insights
Fecal calprotectin (FC) levels in children with juvenile polyps correlate with polyp size. Removing polyps significantly reduces FC levels, indicating their role in elevated markers.
Area of Science:
- Pediatric Gastroenterology
- Colorectal Health
- Inflammatory Markers
Background:
- Fecal calprotectin (FC) is an inflammatory marker.
- Elevated FC levels can indicate gastrointestinal inflammation.
- The relationship between FC and colorectal polyps in pediatric patients requires further investigation.
Purpose of the Study:
- To identify factors associated with fecal calprotectin (FC) levels in pediatric patients diagnosed with colorectal polyps.
- To examine the correlation between polyp characteristics and FC levels.
- To assess the impact of polypectomy on FC levels.
Main Methods:
- A multicenter, retrospective study included 33 pediatric patients (<19 years) undergoing polypectomy for juvenile polyps (JPs).
- Data collected included demographics, colonoscopic and histological findings, and FC levels.
- Statistical analyses, including Pearson correlation and multivariate linear regression, were used to determine factors correlating with FC levels. Pre- and post-polypectomy FC levels were compared.
Main Results:
- Polyp size was the sole factor significantly correlated with FC levels (r=0.75, p<0.001).
- Multivariate analysis confirmed polyp size as a significant predictor of FC levels (adjusted R²=0.5718, β=73.62, p<0.001).
- FC levels decreased significantly post-polypectomy, from a median of 445.2 mg/kg to 26.5 mg/kg (p<0.001).
Conclusions:
- Fecal calprotectin levels are significantly associated with polyp size in pediatric patients with juvenile polyps.
- Polypectomy leads to a substantial reduction in FC levels, suggesting polyps contribute to elevated markers.
Purpose:
We aimed to investigate factors that correlate with fecal calprotectin (FC) levels in children and adolescents with colorectal polyps.
Methods:
Pediatric patients aged <19 years who underwent colonoscopic polypectomy for a juvenile polyps (JPs) and FC tests were simultaneously conducted in a multicenter, retrospective study. Baseline demographics, colonoscopic and histological findings, and laboratory tests, including FC levels, were investigated. Correlations between the factors were investigated, and linear regression analysis revealed factors that correlated with FC levels. FC levels measured after polypectomies were investigated and the FC levels pre- and post-polypectomies were compared.
Results:
A total of 33 patients were included in the study. According to Pearson correlation analysis, the polyp size was the only factor that showed a statistically significant correlation with FC levels (r=0.75, p<0.001). Furthermore, according to the multivariate linear regression analysis, polyp size was the only factor that showed a statistically significant correlation with FC levels (adjusted R =0.5718, β=73.62, p<0.001). The median FC level was 400 mg/kg (interquartile range [IQR], 141.6-1,000 mg/kg), and the median polyp size was 14 mm (IQR, 9-20 mm). Nineteen patients underwent post-polypectomy FC tests. FC levels showed a significant decrease after polypectomy from a median of 445.2 mg/kg (IQR, 225-1,000) to 26.5 mg/kg (11.5-51) (p<0.001).
Conclusion:
FC levels significantly correlated with polyp size in children and adolescents with JPs.
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