Melanoma in situ of the penis: A very rare entity with an even rarer presentation
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Updated: Aug 9, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Afonso Castro1, André Lacerda2, Miguel Fernandes1
1Urology Department, Centro Hospitalar e Universitário de Lisboa Norte, Lisboa, Portugal.
Abstract:
Penile melanoma in situ is a very rare malignant neoplasm. Surgical treatment is the standard approach, although there are no recommendations regarding the extent and best technique. A 28-year-old male presented with a dark-brown macule on the glans, whose biopsy revealed melanoma in situ. A local excision followed by a partial resurfacing was performed, with follow-up revealing no sign of recurrence and good quality of life. Melanoma is a very dangerous tumor due to its metastization potential. The main challenge is early diagnosis. Surgical treatment is the best approach, although it is difficult to balance resection and organ preservation.
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