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Updated: Aug 9, 2025
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Clinical advancement of precision theranostics in prostate cancer
Yue Tan1,2, Zhihui Fang2,3, Yongxiang Tang2
1Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Abstract:
Theranostic approaches with positron emission tomography/computed tomography (PET/CT) or PET/magnetic resonance imaging (PET/MRI) molecular imaging probes are being implemented clinically in prostate cancer (PCa) diagnosis and imaging-guided precision surgery. This review article provides a comprehensive summary of the rapidly expanding list of molecular imaging probes in this field, including their applications in early diagnosis of primary prostate lesions; detection of lymph node, skeletal and visceral metastases in biochemical relapsed patients; and intraoperative guidance for tumor margin detection and nerve preservation. Although each imaging probe shows preferred efficacy in some applications and limitations in others, the exploration and research efforts in this field will eventually lead to improved precision theranostics of PCa.
Insights
Molecular imaging probes using PET/CT and PET/MRI are advancing prostate cancer (PCa) diagnosis and surgery. Ongoing research aims to enhance these theranostic tools for more precise PCa management.
Area of Science:
- Oncology
- Radiology
- Nuclear Medicine
Background:
- Theranostic molecular imaging probes are increasingly used in clinical settings for prostate cancer (PCa).
- These probes aid in diagnosis and image-guided precision surgery for PCa.
Purpose of the Study:
- To provide a comprehensive review of molecular imaging probes for PCa.
- To summarize their applications in diagnosis, metastasis detection, and surgical guidance.
Main Methods:
- Review of current literature on PET/CT and PET/MRI molecular imaging probes in PCa.
- Analysis of probe efficacy in various clinical scenarios.
Main Results:
- Molecular imaging probes show promise in early PCa diagnosis.
- They are effective in detecting lymph node, skeletal, and visceral metastases in relapsed PCa.
- Intraoperative guidance for tumor margin detection and nerve preservation is facilitated.
Conclusions:
- Each imaging probe has specific applications and limitations.
- Continued research and development will improve precision theranostics for PCa.
