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Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
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Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

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Protein arginine methyltransferases in renal development, injury, repair, and fibrosis

Jianjun Yu1, Chao Yu1, Georgia Bayliss2

  • 1Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Frontiers in Pharmacology
|February 23, 2023
PubMed

Insights

Protein arginine methyltransferases (PRMTs) regulate kidney development, injury, and fibrosis. This review summarizes their roles and mechanisms in renal processes, highlighting potential clinical applications.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nephrology

Background:

  • Protein arginine methyltransferases (PRMTs) are enzymes involved in gene transcription and post-translational modifications.
  • Most research on PRMTs has focused on their roles in cancer and other organs.
  • Increasing evidence highlights PRMT expression and function within the kidney.

Purpose of the Study:

  • To review the function and mechanisms of PRMTs in renal development.
  • To summarize the involvement of PRMTs in kidney injury and repair processes.
  • To explore the potential of PRMTs for future clinical applications in nephrology.

Main Methods:

  • Literature review of studies on PRMTs in kidney physiology and pathology.
  • Analysis of mechanisms by which PRMTs regulate renal gene expression.
  • Examination of PRMTs' roles in histone and non-histone substrate methylation within the kidney.

Main Results:

  • PRMTs are expressed in the kidney and play critical roles in renal development.
  • PRMTs are implicated in the pathogenesis of kidney injury and fibrosis.
  • Specific PRMTs influence various stages of renal repair mechanisms.

Conclusions:

  • PRMTs are key regulators of diverse renal processes, including development, injury, repair, and fibrosis.
  • Understanding PRMT mechanisms in the kidney offers therapeutic targets.
  • PRMTs represent a promising area for clinical intervention in kidney diseases.
Keywords:
fibrosisinjurykidneymethylationpost-translational modificationsprotein arginine methyltransferasesrenal developmentrepair

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