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Zein-based nanoparticles: Preparation, characterization, and pharmaceutical application.

Guijin Liu1, Dongyu An1, Junjian Li1

  • 1Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, China.

Frontiers in Pharmacology
|February 23, 2023
PubMed
Summary
This summary is machine-generated.

Zein nanoparticles, derived from a natural plant protein, offer a biocompatible and biodegradable platform for drug delivery. These zein nanoparticles enhance drug stability, bioavailability, and targeting, improving therapeutic outcomes.

Keywords:
characterizationdrug delivery systemnanoparticlepreparationproteinzein

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Area of Science:

  • Biomaterials Science
  • Pharmaceutical Nanotechnology
  • Protein-based Polymers

Background:

  • Zein, a natural, GRAS (Generally Recognized As Safe) plant protein, is renewable, nontoxic, biocompatible, and biodegradable.
  • Significant research has focused on zein-based biomaterials for diverse industrial applications over the last decade.

Purpose of the Study:

  • To review the preparation methods, characterizations, and pharmaceutical applications of zein-based nanoparticles.
  • To highlight the potential of zein nanoparticles in drug delivery systems.

Main Methods:

  • Zein nanoparticles (NPs) with varied nanostructures were prepared using chemical crosslinking, desolvation, dispersion, and micromixing techniques.
  • Characterization of zein NPs focused on their physical and chemical properties relevant to pharmaceutical applications.

Main Results:

  • Zein NPs demonstrate significant potential in drug delivery applications.
  • These nanoparticles can enhance drug stability, increase oral bioavailability, enable controlled drug release, and improve drug targeting efficacy.

Conclusions:

  • Zein NPs offer a promising platform for improving pharmaceutical effects through advanced drug delivery.
  • Further research using quality by design is needed to optimize the relationship between preparation methods, nanostructures, and pharmaceutical properties for scale-up and clinical translation.