Related Experiment Video
Updated: Aug 9, 2025
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.2K
Light Chain Myeloma Precipitating Cryoglobulinemic Vasculitis.
Bilal Saeed1, Samah A Omar1, Robert Jones2
1Medstar Health Internal Medicine Residency Program, Baltimore, MD, USA.
Journal of Community Hospital Internal Medicine Perspectives
|February 23, 2023
Summary
This case study highlights an unusual presentation of light chain multiple myeloma (LCMM) complicated by Type I Cryoglobulinemia (CG). Early recognition of cutaneous signs is crucial for diagnosing this rare but severe complication.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Light chain multiple myeloma (LCMM) is a subtype of multiple myeloma characterized by poor prognosis.
- Cutaneous manifestations in LCMM are rare, and complications like Type I Cryoglobulinemia (CG) are even less common.
Observation:
- An 80-year-old male presented with a two-month history of progressive non-blanching necrotic rash and ulcers on his face, extremities, and oropharynx.
- Initial workup revealed an overabundance of kappa (κ) light chains, elevated free κ/λ ratio, cryoglobulins, and acute kidney injury.
Findings:
- Bone marrow biopsy confirmed 60% plasma cells with κ-light chain predominance, diagnosing κ-predominant LCMM.
- The patient's clinical presentation and laboratory findings were consistent with a diagnosis of Type I Cryoglobulinemia secondary to LCMM.
Implications:
- Atypical cutaneous manifestations in LCMM, such as necrotic rashes and ulcers, should prompt suspicion for underlying cryoglobulinemia.
- Early diagnosis and treatment of cryoglobulinemia in LCMM patients can potentially improve outcomes and direct timely therapeutic interventions.
