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Related Experiment Video

Updated: Aug 9, 2025

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Contribution of microvascular dysfunction to chronic pain.

Terence J Coderre¹

¹Department of Anesthesia and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.

Frontiers in Pain Research (Lausanne, Switzerland)

|February 23, 2023

Summary

Microvascular dysfunction, affecting blood vessels, contributes to chronic pain conditions like complex regional pain syndrome and fibromyalgia. This review explores its role in pain initiation and sensitivity.

Keywords:

antioxidants cytokines endothelial cells ischemia-reperfusion microvascular injury oxidative stress

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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

Area of Science:

Physiology
Pathology
Pain Research

Background:

Microvascular dysfunction is increasingly linked to chronic pain conditions.
Impairments in arterioles, capillaries, and venules affect tissue health and pain signaling.
This dysfunction may initiate pain and alter pain sensitivity.

Purpose of the Study:

To review evidence on the role of microvascular dysfunction in chronic pain.
To discuss its contribution to conditions like complex regional pain syndrome (CRPS) and fibromyalgia.

Main Methods:

Literature review of existing studies.
Analysis of evidence linking microvascular injury to chronic pain pathologies.

Main Results:

Growing evidence supports microvascular dysfunction as a key factor in chronic pain.
Microvascular changes impact tissue integrity and nociception.
Specific conditions like CRPS and fibromyalgia show links to microvascular issues.

Conclusions:

Microvascular dysfunction is a significant contributor to chronic pain.
Targeting microvascular health may offer new therapeutic avenues for pain management.