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Contribution of microvascular dysfunction to chronic pain

Terence J Coderre1

  • 1Department of Anesthesia and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.

Frontiers in Pain Research (Lausanne, Switzerland)
|February 23, 2023
PubMed

Insights

Microvascular dysfunction, affecting blood vessels, contributes to chronic pain conditions like complex regional pain syndrome and fibromyalgia. This review explores its role in pain initiation and sensitivity.

Area of Science:

  • Physiology
  • Pathology
  • Pain Research

Background:

  • Microvascular dysfunction is increasingly linked to chronic pain conditions.
  • Impairments in arterioles, capillaries, and venules affect tissue health and pain signaling.
  • This dysfunction may initiate pain and alter pain sensitivity.

Purpose of the Study:

  • To review evidence on the role of microvascular dysfunction in chronic pain.
  • To discuss its contribution to conditions like complex regional pain syndrome (CRPS) and fibromyalgia.

Main Methods:

  • Literature review of existing studies.
  • Analysis of evidence linking microvascular injury to chronic pain pathologies.

Main Results:

  • Growing evidence supports microvascular dysfunction as a key factor in chronic pain.
  • Microvascular changes impact tissue integrity and nociception.
  • Specific conditions like CRPS and fibromyalgia show links to microvascular issues.

Conclusions:

  • Microvascular dysfunction is a significant contributor to chronic pain.
  • Targeting microvascular health may offer new therapeutic avenues for pain management.
Keywords:
antioxidantscytokinesendothelial cellsischemia-reperfusionmicrovascular injuryoxidative stress

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