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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Prognostic markers for ischemic stroke - are they truly reliable?
Corina Roman-Filip1,2, Maria-Gabriela Catană1,2,3, Romeo-Gabriel Mihăilă2,4
1Department of Neurology, Emergency Clinical County Hospital, Sibiu, Romania.
Inflammation markers like hsCRP, NLR, and PLR show strong correlations with ischemic stroke severity. These markers may aid in predicting stroke prognosis and preventing complications, though not linked to carotid stenosis.
Area of Science:
- Neurology
- Biomarkers
- Inflammation
Background:
- Stroke is a major global cause of death and disability.
- Current biomarkers for ischemic stroke prevention and prognosis are insufficient.
- Further research is needed to understand stroke's underlying mechanisms and identify predictive markers.
Purpose of the Study:
- To investigate the role of inflammation markers in ischemic stroke.
- To determine the correlation between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and high-sensitivity C-reactive protein (hsCRP) with stroke severity.
- To assess the relationship between these inflammation markers and carotid stenosis.
Main Methods:
- Prospective observational study with 150 participants (100 stroke patients, 50 controls).
- Blood samples analyzed for hsCRP, neutrophils, lymphocytes, and platelets.
- Calculation of NLR and PLR ratios.
- Extracranial carotid Doppler ultrasound performed.
Main Results:
- hsCRP, NLR, and PLR were significantly correlated with ischemic stroke severity (NIHSS score).
- A strong correlation was observed for hsCRP and NLR, and a moderate correlation for PLR.
- No significant correlation was found between these inflammation markers and the presence or severity of carotid stenosis.
Conclusions:
- hsCRP, NLR, and PLR show potential as prognostic biomarkers for ischemic stroke.
- These markers may assist in the prevention of stroke-related complications.
- Further validation is needed to establish their clinical utility in stroke management.
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