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Vaccine Innovation Meta-Model for Pandemic Contexts.

Beatriz C Fialho1, Leandro Gauss2, Priscila F Soares1

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Summary
This summary is machine-generated.

Pandemic vaccine research and development (R&D) can be accelerated by over a decade through collaboration and technology. This fast-track approach ensures timely access to safe and effective vaccines during global health crises.

Keywords:
InnovationOutbreakPandemicResearch and developmentVaccine

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Area of Science:

  • Public Health
  • Vaccinology
  • Epidemiology

Background:

  • Infectious disease outbreaks and pandemics pose significant challenges to global health security.
  • Vaccine research and development (R&D) is traditionally a lengthy, complex, and costly process.
  • The COVID-19 pandemic highlighted the urgent need for accelerated vaccine development.

Purpose of the Study:

  • To investigate the paradigm shift in vaccine R&D during pandemic contexts.
  • To analyze the impact of this shift on the vaccine innovation value chain.

Main Methods:

  • A systematic literature review and meta-synthesis of 27 articles and reports published between 2011 and 2021.
  • Focus on studies addressing vaccine R&D in the context of global health threats, outbreaks, epidemics, or pandemics.

Main Results:

  • A meta-model was developed to describe a fast-track R&D process for pandemic contexts.
  • Identified key drivers, innovations, and mechanisms of this accelerated process.
  • Quantified the impact on the vaccine innovation value chain.

Conclusions:

  • Fast-track vaccine R&D, driven by collaboration between regulators, industry, and academia, can reduce development time by an average of 11 years.
  • Leveraging enabling technologies is crucial for accelerating vaccine R&D.
  • Pharmacovigilance and real-world evidence monitoring are essential for ensuring the safety and efficacy of authorized pandemic vaccines.