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Retzius-Sparing Robot-Assisted Radical Prostatectomy

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Solitary Abdominal Wall Lymph Node Recurrence in Prostate Cancer Patient with Dramatic Prostate-Specific Antigen

Andrew Williams¹, Amr A Elbakry², Tyler Trump²

¹West Virginia University, School of Medicine, Morgantown, West Virginia, USA.

Case Reports in Urology

|February 23, 2023

Summary

This summary is machine-generated.

This case study highlights how advanced imaging like prostate-specific membrane antigen positron emission tomography (PSMA PET) can detect recurrence in prostate cancer patients. Metastasis-directed therapy for isolated abdominal wall recurrence led to significant PSA reduction.

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Published on: March 6, 2018

Area of Science:

Oncology
Nuclear Medicine
Urology

Background:

Prostate cancer surveillance relies on prostate-specific antigen (PSA) for detecting recurrence.
Prostate-specific membrane antigen positron emission tomography (PSMA PET) is an advanced imaging technique for localizing recurrent prostate cancer.
Early detection and precise localization of recurrence are crucial for effective patient management.

Observation:

A 55-year-old prostate cancer patient with undetectable post-surgery PSA levels developed a rising PSA to 3.47 ng/mL.
PSMA PET imaging revealed an isolated focus of uptake in an abdominal wall mass.
The patient underwent pelvic lymphadenectomy and abdominal wall mass excision.

Findings:

Histopathology confirmed a single metastasis within an abdominal wall lymph node.
Metastasectomy resulted in a significant decrease in PSA to 0.10 ng/mL postoperatively.
Sustained low PSA levels were observed during long-term follow-up, indicating successful treatment.

Implications:

This case demonstrates the efficacy of metastasis-directed therapy for oligometastatic recurrence of prostate cancer.
PSMA PET imaging plays a pivotal role in identifying the site of recurrence for targeted intervention.
Metastasectomy can be a valuable treatment option for selected cases of delayed, isolated prostate cancer recurrence.