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Painful Foot Lesions: A Case Report.
Trevor J Lockard1, Ritu N Swali1, Melodi Javid Whitley2
1Department of Dermatology, University of Nebraska Medical Center, Omaha, USA.
Cureus
|February 23, 2023
Summary
Hand-foot skin reaction (HFSR), a side effect of tyrosine kinase inhibitor (TKI) chemotherapy, can be managed effectively. Prompt treatment allows patients with advanced cancer to resume life-prolonging chemotherapy sooner.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Hand-foot skin reaction (HFSR) is a known adverse effect of tyrosine kinase inhibitor (TKI) chemotherapy.
- HFSR can cause significant discomfort and complications, potentially interrupting cancer treatment.
- Optimizing survival and tumor remission necessitates continued chemotherapy.
Observation:
- A 66-year-old male with metastatic renal clear cell carcinoma developed grade 3 HFSR.
- The HFSR was triggered by axitinib, a tyrosine kinase inhibitor.
- The patient's chemotherapy was resumed promptly after temporary axitinib cessation and treatment with topical steroids and keratolytics.
Findings:
- Effective management of TKI-induced HFSR is crucial for patient care.
- Swift diagnosis and identification of the causative agent are key to successful treatment.
- A combination of axitinib withdrawal, topical steroids, and keratolytics facilitated rapid recovery.
Implications:
- Increased awareness of TKI-induced HFSR is needed among healthcare professionals.
- Prompt management strategies can enable patients to continue essential, life-prolonging chemotherapy.
- This case highlights the importance of managing chemotherapy side effects to maintain treatment efficacy in advanced malignancies.
