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Structure of microtubules with reduced hydration. Comparison of results from X-ray diffraction and electron
1Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02254.
Journal of Molecular Biology
|August 5, 1987
Abstract:
A recent model for the structure of microtubules is used to interpret X-ray fiber diffraction patterns from microtubules, obtained under various conditions. The results suggest that tubulin may undergo conformational changes under conditions of reduced water-activity. Such changes could account for some of the differences in the structure of tubulin as determined by electron microscopy and X-ray diffraction.