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Published on: July 16, 2020
A rare case of vasculitis in cystic fibrosis: A clinical case
Sabrina Nasreddine1, Mitchelle Issa1, Zeina Aoun Bacha1
1Department of Pulmonology-Critical Care, Hotel Dieu de France UHC, St Joseph University, Beirut, Lebanon.
Introduction:
Cystic fibrosis is known to cause serious complications, such as recurrent pulmonary infections, pancreatic insufficiency, and other symptoms related to exocrine gland dysfunction. A rare manifestation of the disease is discussed in this case of a 24-year-old female diagnosed with cystic fibrosis, a purpuric rash was documented during pulmonary infection flares. Skin biopsy shows a leukocytoclastic vasculitis eruption along with infection. Treatment options are limited and not well established. Our patient received a treatment based on colchicine 1mg per day with a total response. The patient was observed during two consecutive pulmonary infection flares separated by a few months, and a total remission without recurrence was found.
Conclusion:
Considering its efficacy and safety, further scientific research about colchicine and vasculitis in cystic fibrosis should be aimed at in order to define a strong consensus between the disease and this treatment option.
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