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Amniotic membrane as an accelator in mandibular bone defects repair
Mohammad Hasan Samandari1, Alireza Tamizifar1, Mahdi Hosseinian2
1Dental Implant Research Center, Department of Oral and Maxillofacial Surgery, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Dental Research Journal
|February 23, 2023
Summary
The fetal amniotic membrane promotes bone regeneration and reduces inflammation in mandibular defects. This biological graft aids in healing, similar to natural periosteum, offering a promising therapeutic approach.
Area of Science:
- Regenerative Medicine
- Oral Surgery
- Biomaterials Science
Background:
- The fetal amniotic membrane is a biological graft known for wound protection and promoting epithelialization.
- Its unique properties suggest potential applications in tissue repair and regeneration.
Purpose of the Study:
- To evaluate the osteoinductive potential of fetal amniotic membrane in mandibular bone defects.
- To compare bone formation and inflammation levels when amniotic membrane is used with xenograft.
Main Methods:
- Mandibular premolar extraction and defect creation in four dogs.
- Defects were grafted with xenograft, with one side additionally covered by amniotic membrane.
- Bone quantity and histopathological inflammation were assessed after 4 and 8 weeks.
Main Results:
- The amniotic membrane group showed significantly higher bone quantity (56.81) compared to the control group (37.38).
- Inflammation intensity was moderate (50%) in the amniotic membrane group versus severe (62.5%) in the control group.
- Statistical analysis confirmed significant differences (P=0.025 for bone quantity, P=0.041 for inflammation).
Conclusions:
- Fetal amniotic membrane demonstrates positive osteoinduction effects.
- It can aid in the repair of bone defects, acting similarly to natural periosteum.
- This suggests its utility in regenerative procedures for bone defects.
