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Published on: June 27, 2011
Anti-GM-CSF Neutralizing Autoantibodies in Colombian Patients with Disseminated Cryptococcosis
Carlos A Arango-Franco1,2, Mélanie Migaud1,3, Isabel Cristina Ramírez-Sánchez4,5
1Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, 24 Boulevard du Montparnasse, Paris, France.
Three Colombian patients with disseminated cryptococcosis had high levels of neutralizing autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). This finding suggests a potential role for anti-GM-CSF autoantibodies in this fungal infection.
Area of Science:
- Immunology
- Mycology
- Infectious Diseases
Background:
- Cryptococcosis is a serious fungal infection caused by Cryptococcus yeasts.
- Cryptococcal meningitis is the most common human manifestation.
- Neutralizing autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) are linked to cryptococcal meningitis.
Conclusions:
- Disseminated cryptococcosis in these patients was associated with neutralizing autoantibodies against GM-CSF.
- Further research is needed on the genetic basis of autoantibody production and the GM-CSF pathway's role in Cryptococcus infections.
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