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Related Experiment Video

Updated: Aug 9, 2025

Model of Ischemia and Reperfusion Injury in Rabbits
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Intravenous Dabigatran Provides Adequate Anticoagulation for Cardiopulmonary Bypass Using a Rabbit Model.

Sergiy M Nadtochiy1, Tatsiana Stefanos1, Ronald E Angona2

  • 1Department of Anesthesiology and Perioperative Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

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|February 23, 2023
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Summary

Dabigatran effectively prevents thrombosis during cardiopulmonary bypass (CPB) in rabbits, offering an alternative to heparin. This study demonstrates dabigatran

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Area of Science:

  • Cardiovascular Surgery
  • Pharmacology
  • Hematology

Background:

  • Heparin is the standard anticoagulant for cardiopulmonary bypass (CPB).
  • Heparin-induced thrombocytopenia necessitates alternative anticoagulants.
  • Dabigatran shows promise as an anticoagulant for CPB.

Purpose of the Study:

  • To test the hypothesis that dabigatran provides sufficient anticoagulation for CPB in rabbits.
  • To compare dabigatran's efficacy against heparin in a rabbit CPB model.

Main Methods:

  • Nonlinear mixed effects models estimated dabigatran pharmacokinetics in rabbits.
  • Dabigatran infusion maintained target plasma concentrations during CPB.
  • Activated clotting time and thromboelastometry assessed anticoagulation.
  • Histology and electron microscopy evaluated for thrombosis and damage.

Main Results:

  • Dabigatran concentrations exceeded targets but prevented thrombosis during 2-hour CPB.
  • Both dabigatran and heparin showed elevated reaction times.
  • No significant differences in thrombosis or organ damage were observed between groups.
  • Arterial filters showed minimal fibrin in both groups.

Conclusions:

  • Dabigatran provides acceptable anticoagulation for CPB in a rabbit model.
  • Dabigatran is a potential alternative to heparin for CPB.
  • This study is a proof-of-concept for dabigatran use in CPB.