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Association between preoperative hematologic markers and aggressive behavior in meningiomas
Bradley S Guidry1, Silky Chotai2, Alan R Tang1
1Vanderbilt University School of Medicine, Nashville, TN, USA.
Clinical Neurology and Neurosurgery
|February 23, 2023
Summary
Preoperative monocyte-lymphocyte ratio (MLR) may help assess meningioma aggressiveness. While most blood markers did not predict meningioma invasiveness, a higher MLR correlated with a higher proliferation index, aiding risk stratification.
Area of Science:
- Neurosurgery
- Oncology
- Hematology
Background:
- Meningiomas exhibit variable aggressive behavior.
- Predicting meningioma aggressiveness using systemic hematologic markers requires further investigation.
Purpose of the Study:
- To assess the association between preoperative hematologic markers (neutrophil-lymphocyte ratio, neutrophil-monocyte ratio, monocyte-lymphocyte ratio, platelet-lymphocyte ratio, prognostic nutritional index) and meningioma prognostic factors.
- To evaluate these markers against WHO grade, proliferation index, perilesional edema, and tumor recurrence.
Main Methods:
- Retrospective review of 209 patients undergoing intracranial meningioma resection (2000-2019).
- Analysis of preoperative complete blood count differentials and correlation with tumor characteristics.
- Univariate and multivariable regression analyses were performed.
Main Results:
- No significant association was found between hematologic markers and tumor recurrence, perilesional edema, or WHO grade.
- Monocyte-lymphocyte ratio (MLR) was significantly associated with a higher MIB-index (proliferation index) (p=0.018).
Conclusions:
- Most preoperative hematologic markers are not reliable indicators of meningioma invasiveness or grade.
- Preoperative MLR may serve as a surrogate marker for meningioma proliferation and assist in risk stratification.
