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Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
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Mapping the interplay between NK cells and HIV: therapeutic implications.
Renee R Anderko1, Robbie B Mailliard1
1Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, United States.
Journal of Leukocyte Biology
|February 23, 2023
Summary
Natural killer (NK) cells show promise for a functional HIV cure by controlling the virus. Research explores optimizing NK cell responses to achieve sustained remission without antiretroviral therapy (ART).
Area of Science:
- Immunology
- Virology
- Cellular Biology
Background:
- Combination antiretroviral therapy (ART) suppresses HIV-1 but does not eradicate the virus, necessitating lifelong treatment.
- Persistent HIV-1 reservoirs in CD4+ T cells lead to viral rebound after treatment interruption.
- Inflammatory comorbidities are prevalent in treated HIV-1 individuals, highlighting the need for ART-free remission strategies.
Approach:
- This review examines the role of Natural Killer (NK) cells in antiviral immunity against HIV-1.
- It details the impact of HIV-1 infection and ART on NK cell phenotype and function.
- The review discusses the characteristics of memory NK cells and the influence of HCMV on their development in HIV-1 infection.
Key Points:
- NK cells possess pleiotropic effector functions and memory-like capabilities, positioning them as a promising therapeutic modality for HIV-1.
- Understanding NK cell immunobiology in HIV-1 infection is crucial for developing novel treatment strategies.
- Cytomegalovirus (CMV) impacts the induction and expansion of memory NK cells in HIV-1-infected individuals.
Conclusions:
- Optimizing NK cell responses offers a viable pathway towards sustained virologic remission and a functional cure for HIV-1.
- Therapeutic strategies include blocking inhibitory NK receptors, using TLR agonists, CAR NK cells, BiKEs/TriKEs, and bNAbs for ADCC.
- Harnessing NK cell effector functions holds significant potential to transform HIV-1 treatment paradigms.
Keywords:
HIVadaptive NK cellsbroadly neutralizing antibodies (bNAbs)dendritic cells (DCs)innate immune memorymemory NK cellsMore Related Videos
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