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Precision nephrology: from molecular diagnostics to an individualized therapy.

Anne K Mühlig1, Jun Oh2, Tobias B Huber3

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Precision diagnostics are needed for glomerular diseases like minimal change disease and focal segmental glomerulosclerosis. Further studies are essential to advance individualized precision nephrology and molecularly-guided therapies.

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Area of Science:

  • Nephrology
  • Molecular Diagnostics
  • Translational Medicine

Background:

  • Current diagnosis of glomerular diseases relies on histology and immunohistochemistry, lacking molecular insights for personalized treatment.
  • Nephrology is transitioning towards systemic molecular precision diagnostics and individualized therapies.
  • The pace of this transformation depends on successful translational research strategies.

Purpose of the Study:

  • To highlight the need for molecular understanding in glomerular diseases.
  • To propose minimal change disease and focal segmental glomerulosclerosis as models for advancing precision nephrology.
  • To emphasize the importance of translational strategies for individualized therapy.

Main Methods:

  • Review of current diagnostic approaches in glomerular diseases.
  • Analysis of the heterogeneity of minimal change disease and focal segmental glomerulosclerosis.
  • Discussion of the potential for molecular stratification in guiding therapy.

Main Results:

  • Conventional methods fail to provide molecular disease understanding and stratification.
  • Minimal change disease and focal segmental glomerulosclerosis are suitable for exploring precision diagnostics.
  • Translational strategies are key to implementing individualized precision nephrology.

Conclusions:

  • Advancing precision nephrology requires a shift from conventional histology to molecular diagnostics.
  • Minimal change disease and focal segmental glomerulosclerosis serve as ideal models for this transition.
  • Further research exemplifying translational strategies is crucial for individualized glomerular disease therapy.