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Updated: Aug 9, 2025

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
Published on: November 10, 2011
[Attention should be paid to the application of regional citrate anticoagulation in blood purification]
1Department of Nephrology, the First Affiliated Hospital of Sun Yat-sen University/Key Laboratory of Nephrology, National Health Commission/Guangdong Provincial Key Laboratory of Nephrology, Guangzhou 510080, China.
Abstract:
Compared with traditional low-molecular-weight heparin anticoagulation or non-anticoagulant hemodialysis, regional citrate anticoagulation (RCA) has emerged as a promising anticoagulant method considering its satisfactory efficacy, reduced incidence of bleeding, extended life of the dialyzer and increased removal of the toxin. RCA has received more and more attention in recent years which contributes as a first-line anticoagulant regimen for continuous renal replacement therapy, and it gradually gains wide clinical application in maintenance hemodialysis (MHD). In addition, RCA has been reported to be successfully used in plasma exchange and hemoperfusion. This article elaborates on mechanism of RCA and the problems in clinical application, in order to further expand the application of RCA and improve the effect of blood purification in the future.
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