Related Experiment Video
Updated: Aug 9, 2025
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
Targeting pyroptosis in breast cancer: biological functions and therapeutic potentials on It
Cong Chen1, Qianwei Ye1, Linbo Wang2
1Department of Breast Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Abstract:
Pyroptosis is a lytic and inflammatory type of programmed cell death that is mediated by Gasdermin proteins (GSDMs). Attractively, recent evidence indicates that pyroptosis involves in the development of tumors and can serve as a new strategy for cancer treatment. Here, we present a basic knowledge of pyroptosis, and an overview of the expression patterns and roles of GSDMs in breast cancer. In addition, we further summarize the available evidence of pyroptosis in breast cancer progression and give insight into the clinical potential of applying pyroptosis in anticancer strategies for breast cancer. This review will deepen our understanding of the relationship between pyroptosis and breast cancer, and provide a novel potential therapeutic avenue for breast cancer.
Insights
Pyroptosis, a programmed cell death involving Gasdermin proteins, is implicated in tumor development. Targeting pyroptosis offers a novel therapeutic strategy for breast cancer treatment.
Area of Science:
- Oncology
- Cell Biology
- Immunology
Background:
- Pyroptosis is a lytic, inflammatory programmed cell death pathway.
- Gasdermin proteins (GSDMs) mediate pyroptosis.
- Emerging evidence links pyroptosis to tumor development and cancer therapy.
Purpose of the Study:
- To provide foundational knowledge of pyroptosis.
- To review GSDM expression and roles in breast cancer.
- To explore pyroptosis's clinical potential in breast cancer treatment.
Main Methods:
- Literature review of pyroptosis mechanisms.
- Analysis of GSDM expression patterns in breast cancer.
- Synthesis of evidence on pyroptosis in breast cancer progression.
Main Results:
- GSDMs play significant roles in breast cancer.
- Pyroptosis is involved in breast cancer progression.
- Pyroptosis modulation presents a potential therapeutic avenue.
Conclusions:
- Understanding pyroptosis deepens insights into breast cancer.
- Targeting pyroptosis offers a novel strategy for breast cancer therapy.
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
02:38Mitogens and the Cell Cycle