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Updated: Jun 18, 2026

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
Published on: April 30, 2011
High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq
Yang Liu1,2,3,4,5, Marcello DiStasio3,4,5, Graham Su1,2
1Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
None:
In this study, we extended co-indexing of transcriptomes and epitopes (CITE) to the spatial dimension and demonstrated high-plex protein and whole transcriptome co-mapping. We profiled 189 proteins and whole transcriptome in multiple mouse tissue types with spatial CITE sequencing and then further applied the method to measure 273 proteins and transcriptome in human tissues, revealing spatially distinct germinal center reactions in tonsil and early immune activation in skin at the Coronavirus Disease 2019 mRNA vaccine injection site.
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