Related Experiment Video

Updated: Aug 9, 2025

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Early identification and treatment for peripheral arterial disease in patients with ischemic cerebrovascular disease

Lu-Guang Li1,2,3, Xin Ma4,5,6

  • 1Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.

European Journal of Medical Research
|February 24, 2023
PubMed

Insights

Ischemic cerebrovascular disease (ICVD) patients with peripheral arterial disease (PAD) face worse outcomes. Duplex ultrasound aids PAD screening in ICVD patients, with antiplatelet therapy and new antithrombotics showing promise for stroke prevention.

Area of Science:

  • Vascular Medicine
  • Neurology
  • Cardiology

Background:

  • Ischemic cerebrovascular disease (ICVD) is a leading cause of death and disability globally, frequently linked to atherosclerosis.
  • Atherosclerosis is a systemic condition affecting multiple arteries, often leading to coexistent lower-extremity peripheral arterial disease (PAD) in ICVD patients.
  • ICVD patients with PAD experience more severe symptoms and poorer prognoses, yet PAD evaluation and management are often overlooked by neurologists.

Purpose of the Study:

  • To review current research on diagnosing and managing PAD in ICVD patients.
  • To highlight effective diagnostic tools and therapeutic strategies for this patient population.
  • To address the lack of consensus in clinical practice regarding coexistent PAD in ICVD.

Main Methods:

  • Literature review summarizing recent research progress.
  • Evaluation of diagnostic methods for PAD in ICVD patients.
  • Analysis of current and emerging antithrombotic treatment strategies.

Main Results:

  • Duplex ultrasound demonstrates advantages for early screening and evaluation of PAD in ICVD patients compared to other methods.
  • Single-drug antiplatelet therapy is supported as a foundational treatment.
  • Novel antithrombotic strategies, including ticagrelor monotherapy or aspirin with low-dose rivaroxaban, show potential for reducing stroke incidence.

Conclusions:

  • Early screening for PAD using duplex ultrasound is recommended for ICVD patients.
  • Current evidence supports antiplatelet therapy, with newer antithrombotic regimens offering improved stroke prevention.
  • Further large-scale trials are needed to guide optimal clinical management and secondary stroke prevention in ICVD patients with PAD.

Keywords:
CoexistenceDiagnosisIschemic cerebrovascular diseasePeripheral arterial diseaseTherapy

More Related Videos

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

1.6K
Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication14:52

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

11.5K

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
17
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
23
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
15
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
19
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
23
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
16