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Intestinal Submucosal Mucinosis in a Patient With Systemic Lupus Erythematosus: A Case Report
Che-Wei Hsu1, Chien-An Chu1, Chia-Tse Weng2
1Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
International Journal of Surgical Pathology
|February 24, 2023
Summary
Systemic lupus erythematosus (SLE) can affect the gastrointestinal tract. This case report details a rare instance of mucin deposition in the intestines of an SLE patient, mimicking colitis.
Area of Science:
- Gastroenterology
- Rheumatology
- Dermatology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disorder.
- Mucin deposition is a known feature in SLE skin lesions.
- Gastrointestinal involvement in SLE is diverse, but mucinosis is exceedingly rare.
Observation:
- A patient with SLE presented with erythematous patches spanning the terminal ileum to the anus.
- Clinical diagnosis suggested diffuse colitis.
- Histopathological examination revealed inflammatory cell infiltration and abundant submucosal mucinous material.
Findings:
- The deposited mucin stained positive with Alcian blue (pH 2.5).
- The mucinous material was susceptible to hyaluronidase digestion.
- These histochemical properties align with cutaneous mucinosis observed in SLE.
Implications:
- This represents the first reported case of gastrointestinal tract mucinosis in SLE.
- Highlights the potential for SLE to manifest with unusual gastrointestinal pathology.
- Suggests a possible systemic basis for mucin deposition in SLE beyond the skin.
