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Hypertension, sleep quality, depression, and cognitive function in elderly: A cross-sectional study.
Jiajie Chen1, Xi Chen1, Ruxue Mao1
1Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in Aging Neuroscience
|February 24, 2023
Summary
In older adults, hypertension negatively impacts cognitive function, with sleep quality and depression acting as significant mediators. Monitoring these factors is crucial for maintaining cognitive health in hypertensive individuals.
Area of Science:
- Geriatric Medicine
- Neuroscience
- Psychiatry
Background:
- Hypertension, sleep disorders, and depression are common in the elderly and linked to cognitive impairment.
- The specific mediating roles of sleep quality and depression in the hypertension-cognition link remain unclear.
Purpose of the Study:
- To investigate the mediating roles of sleep quality and depression in the association between hypertension and cognitive impairment in older adults.
Main Methods:
- Cross-sectional study using data from the Tongji Hospital Comprehensive Geriatric Assessment Database.
- Sleep quality (PSQI), depression (GDS-15), and cognitive function (MMSE) were assessed.
- Correlation, regression, and Bootstrap analyses were employed, with Benjamini-Hochberg adjustment for multiple comparisons.
Main Results:
- Of 827 participants, 68.3% had hypertension. Hypertensive elderly individuals exhibited poorer cognitive function, sleep quality, and higher depression levels.
- Sleep quality negatively correlated with depression and cognitive function; depression negatively correlated with cognitive function.
- Mediation analysis confirmed that sleep quality and depression mediate the relationship between hypertension and cognitive function via single and chain pathways.
Conclusions:
- Sleep quality and depression significantly mediate the association between hypertension and cognitive function in the elderly.
- Close monitoring of sleep quality and depression in hypertensive older adults may help preserve cognitive function.
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