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The role of (pro)renin receptor and its soluble form in cardiovascular diseases

Boyang Wang1,2,3, Haipeng Jie1,2, Shuangxi Wang4

  • 1Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Frontiers in Cardiovascular Medicine
|February 24, 2023
PubMed

Insights

The (Pro)renin receptor (PRR) plays a role in cardiovascular diseases by influencing tissue inflammation and fibrosis. Targeting PRR and its soluble form offers potential therapeutic strategies for various cardiovascular conditions.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Renal Physiology

Background:

  • The renin-angiotensin system (RAS) is a key regulator of cardiovascular homeostasis.
  • Local tissue RAS, distinct from circulating RAS, contributes to inflammation and fibrosis.
  • (Pro)renin receptor (PRR) is a novel component of the RAS, identified in 2002.

Purpose of the Study:

  • To review the multifaceted roles of PRR and its soluble form in cardiovascular physiology and pathology.
  • To explore the therapeutic potential of targeting PRR in cardiovascular diseases.
  • To discuss the challenges and opportunities associated with PRR-based therapies.

Main Methods:

  • Literature review of studies on PRR and cardiovascular diseases.
  • Analysis of PRR's involvement in hypertension, ischemia-reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis.
  • Examination of PRR's function in tissue RAS and lysosome biology.

Main Results:

  • PRR significantly impacts cardiovascular pathogenesis through tissue-specific RAS.
  • PRR's role extends beyond RAS, influencing lysosome function and cell survival.
  • Evidence suggests PRR and its soluble form are implicated in diverse cardiovascular conditions.

Conclusions:

  • PRR and its soluble form are critical players in cardiovascular disease development.
  • Targeting PRR presents a promising avenue for novel cardiovascular therapeutics.
  • Further research is needed to overcome challenges in developing PRR-based treatments.
Keywords:
(pro)renin receptorcardiovascular diseasefibrosishypertensionrenin-angiotensin system

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