Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topography and functional traits shape the distribution of key shrub plant functional types in low-Arctic tundra.

Frontiers in plant science·2026
Same author

Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration.

Gels (Basel, Switzerland)·2025
Same author

High-throughput bioprinting of spheroids for scalable tissue fabrication.

Nature communications·2024
Same author

Applications of Diels-Alder Chemistry in Biomaterials and Drug Delivery.

Macromolecular bioscience·2024
Same author

High-Throughput Bioprinting of Spheroids for Scalable Tissue Fabrication.

bioRxiv : the preprint server for biology·2024
Same author

Posttranscriptional Modification to Modulate Progenitor Differentiation on Heterotypic Spheroids.

Tissue engineering. Part A·2024

Related Experiment Video

Updated: Aug 9, 2025

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

9.4K

Developing a clinical grade human adipose decellularized biomaterial.

Daniel J Hayes1, Jeffrey M Gimble2

  • 1Department of Biomedical Engineering, Pennsylvania State University, State College, PA, USA.

Biomaterials and Biosystems
|February 24, 2023
PubMed
Summary
This summary is machine-generated.

Decellularized adipose tissue, rich in extracellular matrix, shows promise as a biomaterial for tissue engineering. Early clinical trials indicate safety and potential for supporting cell growth and tissue regeneration.

Keywords:
ASC, Adipose stromal/stem cellAdiposeBiomaterialCD4, Cluster of differentiation 4ECM, Extracellular matrixM2, alternatively activated macrophageMTF, Musculoskeletal Transplant FoundationScaffoldStromal/Stem Cell

More Related Videos

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization
09:14

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization

Published on: October 20, 2019

9.8K
Decellularization of Whole Human Heart Inside a Pressurized Pouch in an Inverted Orientation
06:28

Decellularization of Whole Human Heart Inside a Pressurized Pouch in an Inverted Orientation

Published on: November 26, 2018

11.4K

Related Experiment Videos

Last Updated: Aug 9, 2025

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

9.4K
Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization
09:14

Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization

Published on: October 20, 2019

9.8K
Decellularization of Whole Human Heart Inside a Pressurized Pouch in an Inverted Orientation
06:28

Decellularization of Whole Human Heart Inside a Pressurized Pouch in an Inverted Orientation

Published on: November 26, 2018

11.4K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Adipose tissue is recognized for its stromal/stem cells.
  • Emerging research highlights adipose tissue's potential as a decellularized matrix resource.

Purpose of the Study:

  • To explore the utility of decellularized adipose tissue as a biomaterial.
  • To review the potential benefits of adipose tissue as an extracellular matrix resource.

Main Methods:

  • Extraction of lipids, DNA, and proteins from human fat to yield decellularized extracellular matrix.
  • Pre-clinical studies in murine and porcine models to assess compatibility and adipogenesis support.
  • Phase I clinical trials evaluating safety in human volunteers.

Main Results:

  • Decellularized adipose tissue matrix is rich in collagen, glycoproteins, and proteoglycans.
  • Demonstrated compatibility with stromal/stem cells and supported adipogenesis in vitro and in vivo.
  • Phase I trials showed safety of decellularized human adipose tissue scaffolds up to 127 days.

Conclusions:

  • Decellularized adipose tissue represents an under-appreciated biomaterial resource.
  • Its composition and demonstrated safety support its use in tissue engineering applications.
  • Obesity may represent an increasingly available source for this valuable biomaterial.