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Updated: Aug 9, 2025

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

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Published on: March 8, 2017

Cochlear transcriptome analysis of an outbred mouse population (CFW).

Ely Cheikh Boussaty¹, Neil Tedeschi², Mark Novotny²

¹Department of Otolaryngology, University of California, San Diego, CA.

Biorxiv : the Preprint Server for Biology

|February 24, 2023

Summary

Age-related hearing loss (ARHL) is common in older adults. This study maps aging cochlear cell types, revealing specific cell changes linked to hearing loss, offering new therapeutic targets.

Keywords:

age-related hearing loss cell ontology genetic determinants of hearing loss marker genes single nucleus RNA sequencing

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Last Updated: Aug 9, 2025

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

Published on: January 12, 2015

Cochlear Surface Preparation in the Adult Mouse

Cochlear Surface Preparation in the Adult Mouse

Published on: November 6, 2019

Area of Science:

Otolaryngology
Genomics
Cell Biology

Background:

Age-related hearing loss (ARHL) is a prevalent condition in the elderly, with its genetic underpinnings not fully understood.
Identifying specific genes, cell types, and pathways involved in ARHL is crucial for developing effective therapeutic interventions.

Conclusions:

This research elucidates cellular and molecular mechanisms driving age-related hearing loss.
Specific cochlear cell subtypes are implicated in hearing acuity decline.
The findings offer novel pathways for therapeutic targeting in ARHL.