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Regulation of secretory pathway kinase or kinase-like proteins in human cancers

Shaonan Du1, Chen Zhu2, Xiaolin Ren3

  • 1Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in Immunology
|February 24, 2023
PubMed

Insights

Secretory pathway kinase or kinase-like proteins (SPKKPs) play a role in human cancer development and immunity. Targeting SPKKPs presents a promising new strategy for anticancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Secretory pathway kinase or kinase-like proteins (SPKKPs) function within the endoplasmic reticulum, Golgi apparatus, and extracellular space.
  • These proteins are integral to secretory signaling pathways and differ from conventional protein kinases.
  • SPKKPs regulate crucial physiological and pathological processes through substrate phosphorylation.

Purpose of the Study:

  • To review the current understanding of SPKKPs' roles in tumorigenesis and immune progression.
  • To highlight the potential of SPKKPs as therapeutic targets in cancer treatment.

Main Methods:

  • Literature review of existing research on SPKKPs in cancer and immunity.
  • Analysis of regulatory factors influencing SPKKP expression in human cancers.

Main Results:

  • SPKKPs are implicated in the regulation of human cancer tumorigenesis and progression.
  • Expression of SPKKPs in cancers is influenced by various regulatory factors.
  • SPKKPs are involved in the progression of immunity within the context of cancer.

Conclusions:

  • SPKKPs are significant contributors to cancer development and immune response.
  • Targeting SPKKPs offers a novel and potentially effective approach for anticancer immunotherapy.
Keywords:
SPKKPskinasemicroenvironmentsecretory pathwaytumor

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