Non-coding RNAs targeting NF-κB pathways in aquatic animals: A review

Area of Science:

• Molecular Biology
• Immunology
• Aquatic Animal Health

Background:

• Nuclear Factor-kappa B (NF-κB) pathways are crucial for inflammation and immune responses in many diseases.
• Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, regulate cellular functions without protein products.
• Research on ncRNA regulation of NF-κB pathways in aquatic animals is limited.

Purpose of the Study:

• To comprehensively review the roles of ncRNAs in targeting NF-κB pathways in aquatic animals.
• To provide new insights into the regulatory mechanisms of NF-κB pathways in aquatic species.
• To explore potential antiviral applications of ncRNAs in fisheries.

Main Methods:

• Literature review of existing studies on ncRNAs and NF-κB pathways in aquatic animals.
• Analysis of confirmed regulatory mechanisms between ncRNAs and NF-κB signaling.
• Synthesis of current knowledge to identify research gaps and future directions.

Main Results:

• Several studies have elucidated specific regulatory mechanisms between ncRNAs and NF-κB pathways in aquatic organisms.
• ncRNAs play significant roles in modulating immune and inflammatory responses mediated by NF-κB in fish and other aquatic species.
• The review highlights the conserved nature of some ncRNA-NF-κB interactions across different species.

Conclusions:

• ncRNAs represent a key regulatory layer for NF-κB pathways in aquatic animals.
• Understanding these interactions is vital for advancing aquatic immunology and disease resistance.
• ncRNA-based strategies hold promise for developing novel antiviral treatments in aquaculture and fisheries.