Related Experiment Video
Updated: Aug 9, 2025
Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
Published on: May 2, 2022
Cardiovascular-Specific Mortality among Gastrointestinal Stromal Tumor Patients: A Population-Based Analysis
Hailing Yao1, Huiying Shi1, Mengke Fan1
1Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Insights
Cardiovascular mortality risk is significantly elevated in gastrointestinal stromal tumor (GIST) patients compared to the general population. Early screening and interventions are crucial for GIST survivors to prevent heart disease deaths.
Area of Science:
- Oncology
- Cardiology
- Epidemiology
Background:
- Cancer survivors face increased cardiovascular mortality (CVM) risk over time.
- The specific CVM trends in gastrointestinal stromal tumor (GIST) patients are not well-established.
- This study investigates CVM risks and predictors in GIST patients.
Purpose of the Study:
- To assess the overall risk of cardiovascular mortality in patients diagnosed with GIST.
- To identify independent predictors associated with cardiovascular mortality in this patient group.
Main Methods:
- Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019).
- Employed standardized mortality ratio (SMR) to evaluate CVM risk.
- Applied a multivariate competing risk model to identify CVM predictors.
Main Results:
- Included 12,058 GIST patients; 4.0% died from cardiovascular disease (CVD).
- GIST patients exhibited a significantly higher CVM risk (SMR: 3.23) versus the general population.
- Older age, male sex, White race, unmarried status, earlier diagnosis year, and no chemotherapy were poor prognostic factors for CVM.
Conclusions:
- Gastrointestinal stromal tumor patients face a substantially elevated risk of cardiovascular mortality.
- Implementing timely cardiovascular screening and protective interventions is recommended for GIST patients to mitigate CVM.
Background:
The overall risk of cardiovascular mortality (CVM) in cancer survivors has increased with time. The trend of CVM in patients with gastrointestinal stromal tumors (GISTs) remains unclear. This study is aimed at assessing the risks and independent predictors of CVM in GIST patients.
Methods:
Data of the GIST patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019). The standardized mortality ratio (SMR) was used to evaluate the risk of CVM, and a multivariate competing risk model was utilized to identify the predictors for CVM.
Results:
A total of 12,058 patients with GIST were included in this study, of whom 477 (4.0%) patients died of cardiovascular disease (CVD). The SMR for CVM among GIST patients was significantly higher than in the general population (SMR, 3.23, 95% CI: 2.97-3.52), and all categories of CVD were associated with a significantly elevated SMR. The cumulative mortality of CVD was the lowest among all causes of death, while the CVM was the second most common cause of death in patients ≥ 80 years when stratified by age at diagnosis. Furthermore, male sex, older age at diagnosis, White race, unmarried, earlier year of diagnosis, and not receiving chemotherapy were the poor prognostic factors for CVM.
Conclusions:
The CVM risk in GIST patients was significantly higher relative to the general US population. Timely screening and cardioprotective interventions should be implemented to prevent the occurrence of CVM in patients with GIST.
More Related Videos
05:16Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024