Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Streptavidin Functionalized Hyaluronic Acid Hydrogels for Controlled and Customizable Drug Delivery.

Acta biomaterialia·2026
Same author

Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites.

Advanced functional materials·2026
Same author

Advances in light-based 3D bioprinting.

Biofabrication·2026
Same author

Synovial fibroblasts modulate endothelial activation in an acute injury-on-a-chip model.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Dynamic Self-Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Engineering and Exploring Hydrolytic Degradation in 3D-Printed Liquid Crystalline Elastomers.

Biomacromolecules·2026

Related Experiment Video

Updated: Aug 9, 2025

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

5.8K

Granular hydrogels for endogenous tissue repair.

Taimoor H Qazi1, Jason A Burdick1

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Biomaterials and Biosystems
|February 24, 2023
PubMed
Summary

Granular hydrogels, composed of microgels, are innovative scaffolds that guide cell behavior for tissue repair. Their tunable properties and injectability enable multifunctional designs for enhanced healing.

Keywords:
Granular hydrogelHydrogelMicrogelTissue engineering

More Related Videos

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

7.0K
Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials
08:53

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials

Published on: March 7, 2025

698

Related Experiment Videos

Last Updated: Aug 9, 2025

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

5.8K
Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

7.0K
Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials
08:53

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials

Published on: March 7, 2025

698

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Granular hydrogels, formed by packing hydrogel microparticles (microgels), are an emerging class of biomaterials.
  • They offer advantages over traditional scaffolds, including injectability, inherent porosity, and potential for biologics delivery.
  • Their design allows for tuning microgel properties and mixing populations for multifunctional applications.

Purpose of the Study:

  • To explore the potential of granular hydrogels in supporting endogenous tissue repair.
  • To highlight the design modularity and resulting functionalities of granular hydrogels.
  • To demonstrate how granular hydrogels can guide cell behavior for tissue regeneration.

Main Methods:

  • Fabrication of granular hydrogels from tunable hydrogel microparticles.
  • Characterization of microgel and granular hydrogel properties.
  • Assessment of granular hydrogel interactions with cells and their ability to influence tissue growth.

Main Results:

  • Granular hydrogels demonstrate injectability and inherent porosity.
  • The modular design allows for the creation of multifunctional materials.
  • These hydrogels effectively guide cell recruitment, extracellular matrix deposition, and tissue growth.

Conclusions:

  • Granular hydrogels represent a promising platform for promoting endogenous tissue repair.
  • Their tunable and modular nature enables the development of advanced regenerative therapies.
  • These materials offer a novel approach to guiding cellular processes for improved healing outcomes.