Nitroarenes and nitroalkenes as potential amino sources for the synthesis of N-heterocycles
Dong Zou1, Wei Wang2, Yaqin Hu1
1Department of Pharmacy, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang, University, Hangzhou, Zhejiang, 310016, China. zoudong16@zju.edu.cn.
Abstract:
Nitro-compounds are one of the cheapest and most readily available materials in the chemical industry and are commonly utilized as versatile building blocks. Previously, the synthesis of N-heterocycles was largely based on anilines. The utilization of nitroarenes and nitroalkenes for the synthesis of N-heterocyclic compounds can save at least one step, however, as compared to anilines. Thus, considerable attention has been paid to nitroarenes and nitroalkenes as new potential amino sources. Significant progress has been made in the reductive cyclization of nitroarenes or nitroalkenes to access various N-heterocycles in recent years. Herein, we comprehensively summarize the recent progress in the construction of N-heterocycles using nitroarenes and nitroalkenes as potential amino sources. The compatibility of the reaction substrate, its mechanism, applications, advantages, and limitations in this field are also discussed in detail.
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