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Diverse roles of UBE2T in cancer (Review)

Nengqian Ma1, Zhangzhan Li2, Jingting Yan3

  • 1Department of Hepatobiliary Surgery, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Zhuhui, Hengyang, Hunan 421002, P.R. China.

Oncology Reports
|February 24, 2023
PubMed

Insights

Aberrant ubiquitination, particularly involving ubiquitin-conjugating enzyme E2 T (UBE2T), is implicated in various cancers. Further research is needed to explore UBE2T

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer pathogenesis involves genetic and epigenetic alterations.
  • Aberrant ubiquitination is a key epigenetic disruption in cancer.
  • Ubiquitin-conjugating enzyme E2 T (UBE2T) is increasingly recognized for its role.

Purpose of the Study:

  • To review the role of UBE2T in pan-cancer pathogenesis.
  • To explore UBE2T's association with chemotherapy and radiotherapy sensitivity.
  • To examine small-molecule modulators targeting ubiquitination for cancer treatment.

Main Methods:

  • Comprehensive investigation of UBE2T expression landscape and functional significance.
  • Analysis of UBE2T's correlation with treatment sensitivity.
  • Review of clinical trial data on ubiquitin enzymes and the ubiquitin-proteasome system.

Main Results:

  • Evidence indicates UBE2T plays significant roles in pan-cancer.
  • Aberrant UBE2T is linked to cancer development and progression.
  • Ubiquitin enzymes are crucial components of the ubiquitin-proteasome system.

Conclusions:

  • UBE2T is a critical factor in pan-cancer.
  • Further studies are essential to validate UBE2T as a biomarker or therapeutic target.
  • Targeting ubiquitination pathways offers potential cancer treatment strategies.
Keywords:
cancerchemosensitivitypathwayradiosensitivityubiquitin conjugating enzyme E2 T

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