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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Recent Progresses in Chalcone Derivatives as Potential Anticancer Agents.

Jiahui Yang1, Jianmei Lv1, Shuxian Cheng1

  • 1School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, 050017, China.

Anti-Cancer Agents in Medicinal Chemistry
|February 24, 2023
PubMed
Summary
This summary is machine-generated.

Chalcone hybrids show promising anticancer activities, offering a versatile platform for developing novel, potent, and selective cancer therapeutics. This review highlights their structures and efficacy for future drug design.

Keywords:
Anticancer activitychalconesflavonoidfunctional groupsnatural productsynthesis

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Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Oncology

Background:

  • Chalcones, flavonoid intermediates, are vital precursors for synthesizing therapeutic compounds with diverse biological activities.
  • Cancer remains a leading global cause of death, necessitating the development of safer and more effective anticancer agents.
  • Chalcone derivatives are increasingly recognized for their potential in oncology due to their broad-spectrum biological applications.

Conclusions:

  • Chalcone hybrids represent a promising class of compounds for anticancer drug development.
  • The structural diversity of chalcones facilitates the design of novel molecules with enhanced medicinal properties.
  • Further research into chalcone hybrids can lead to more selective and potent cancer therapeutics.