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Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
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Disarm The Bacteria: What Temperate Phages Can Do

Shiyue Zhou1,2, Zhengjie Liu2, Jiaoyang Song2

  • 1College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

Current Issues in Molecular Biology
|February 24, 2023
PubMed

Insights

Temperate phages, often overlooked, show promise in combating bacterial infections. Their roles in reducing virulence, degrading biofilms, and genetic engineering highlight their potential in clinical applications.

Area of Science:

  • Microbiology
  • Bacteriophage Therapy
  • Genetic Engineering

Background:

  • Virulent phages dominate phage applications, overshadowing temperate phages.
  • Temperate phages carry concerns regarding virulence and drug-resistance genes.
  • Temperate phages also influence bacterial regulation.

Purpose of the Study:

  • To review the biological properties of temperate phages.
  • To highlight recent advancements in temperate phage applications.
  • To assess the potential of temperate phages in clinical settings.

Main Methods:

  • Literature review of temperate phage biology and applications.
  • Analysis of temperate phage life cycles.
  • Synthesis of current research on host virulence reduction, biofilm degradation, genetic engineering, and phage display.

Main Results:

  • Temperate phages possess versatile applications beyond their perceived drawbacks.
  • Their roles include reducing bacterial virulence and degrading biofilms.
  • Applications in genetic engineering and phage display are emerging.

Conclusions:

  • Temperate phages offer a promising alternative for tackling bacterial infections.
  • Their inherent properties like host specificity and accessibility are advantageous.
  • Further research can unlock their full therapeutic potential.
Keywords:
biofilm degradationgenetic engineering and modificationhost virulence reductiontemperate phages

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