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Formulation of Zinc-Based Nanomaterials using the Eucommia ulmoides Bark Extract and their Wound Healing Potential

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Diosmin-Loaded Nanoemulsion-Based Gel Formulation: Development, Optimization, Wound Healing and Anti-Inflammatory

Md Khalid Anwer¹, Mohammed F Aldawsari¹, Muzaffar Iqbal^2,3

¹Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia.

Gels (Basel, Switzerland)

|February 24, 2023

Summary

This summary is machine-generated.

This study developed a diosmin-loaded nanoemulsion gel to enhance wound healing. The novel formulation demonstrated significant anti-inflammatory and wound-healing properties in rat models.

Keywords:

Box–Behnken design anti-inflammatory activity gel nanoemulsion wound healing

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Published on: December 13, 2024

Area of Science:

Biomaterials Science
Dermatology
Nanotechnology

Background:

Chronic wounds pose a significant clinical challenge due to complex healing processes.
Engineered biomaterials offer a promising strategy for advanced wound care.
Diosmin (DSM) is a flavonoid with potential therapeutic properties for wound healing.

Purpose of the Study:

To formulate and characterize a novel diosmin (DSM)-loaded nanoemulsion (NE)-based gel.
To evaluate the wound healing and anti-inflammatory efficacy of the developed DSM-loaded NE gel in a rat model.

Main Methods:

Nanoemulsions (NEs) loaded with diosmin (DSM) were prepared using lauroglycol 90, Tween-80, and transcutol-HP.
Formulations were optimized using Box-Behnken Design, focusing on globule size, PDI, and %EE.
The optimized NE formulation (F1) was incorporated into a carbopol 940 gel for further evaluation.

Main Results:

Optimized DSM-loaded NEs exhibited a globule size of 41 ± 0.07 nm, PDI of 0.073 ± 0.008, and %EE of 87 ± 0.81%.
The F1-loaded gel showed favorable characteristics including drug content and spreadability.
In vitro release studies and in vivo assessments demonstrated significant wound-healing and anti-inflammatory activities (p < 0.05).

Conclusions:

A stable and effective diosmin-loaded nanoemulsion gel formulation was successfully developed.
The nanoemulsion gel formulation significantly promotes wound healing and exhibits anti-inflammatory effects.
This formulation represents a promising therapeutic approach for managing cutaneous wounds.