Related Experiment Video
Updated: Aug 9, 2025
07:31
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
3.7K
Study on the effect of artificial joint replacement for osteosarcoma
Shuming Hou1, Xiangzhi Ni, Jing Wang
1Department of Orthopaedic Oncology, Changzheng Hospital of the Navy Medical University, Shanghai, China.
Medicine
|February 24, 2023
Summary
Artificial total femoral replacement is an effective limb salvage surgery for osteosarcoma, significantly improving patient quality of life and function. This procedure preserves limbs, reduces trauma, and enhances mobility in young patients.
Area of Science:
- Orthopedic Surgery
- Oncology
- Biomedical Engineering
Background:
- Osteosarcoma is a primary malignant bone tumor predominantly affecting adolescents and young adults.
- Artificial total femoral replacement offers a limb-salvage alternative to amputation for femoral osteosarcoma.
- This surgery aims to preserve limb function, weight-bearing capacity, and improve patients' quality of life.
Purpose of the Study:
- To evaluate the treatment methods and therapeutic outcomes of artificial total femoral replacement in patients with femoral osteosarcoma.
- To assess the efficacy of limb salvage surgery in managing this aggressive bone tumor.
Main Methods:
- Retrospective analysis of clinical data from 11 patients (7 males, 4 females; age 11-40 years) who underwent artificial total femoral replacement for femoral osteosarcoma between January 2019 and March 2022.
- Patients were assessed using the Visual Analog Scale (VAS) for pain and quality of life scores pre-operatively and at 3 months post-operatively.
- Functional outcomes were evaluated using the Musculoskeletal Tumor Society (MSTS) score and Harris hip score at the most recent follow-up (average 21 months; range 6-58 months).
Main Results:
- Significant improvements were observed in VAS pain scores (5.94 to 3.68) and quality of life scores (22.42 to 40.04) at 3 months post-surgery (P < .05).
- Average MSTS score was 22.5 and average Harris hip score was 69.0 at the final follow-up.
- Low complication rates were reported, with no instances of wound infection, joint dislocation, or nerve damage; one case of popliteal vein thrombus occurred. Two patients died due to tumor progression.
Conclusions:
- Artificial total femoral replacement is a safe and effective limb salvage procedure for treating femoral osteosarcoma.
- The surgery leads to significant pain reduction, improved quality of life, and satisfactory functional outcomes.
- It represents a viable option for preserving limb function and enhancing patient well-being in the context of osteosarcoma treatment.
