Cutting Edge Aquatic-Based Collagens in Tissue Engineering

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Regenerative Medicine
• Biotechnology

Background:

• Collagen is a key component of the human extracellular matrix, crucial for tissue structure and function.
• Mammalian collagen, while widely used, faces limitations including immunological risks, religious restrictions, and higher costs.
• Aquatic-derived collagen presents a viable alternative with distinct advantages for biomedical applications.

Purpose of the Study:

• To provide a comprehensive overview of aquatic collagen's characteristics, extraction, and fabrication methods.
• To highlight the potential applications of aquatic collagen in tissue engineering and regenerative medicine.
• To review recent advancements, future prospects, and challenges associated with aquatic collagen as a biomaterial.

Main Methods:

• Literature review of existing research on aquatic collagen.
• Analysis of physical and biochemical properties of aquatic collagen.
• Exploration of extraction and fabrication techniques for aquatic collagen.
• Assessment of application potential in bone, cartilage, dental, skin, and vascular tissue regeneration.

Main Results:

• Aquatic collagen exhibits excellent biocompatibility and biodegradability.
• Extraction is generally straightforward, with lower immunological risk and production costs compared to mammalian collagen.
• Utilization of aquatic waste provides environmental sustainability and high added value.
• Demonstrated potential for regenerating various human tissues.

Conclusions:

• Aquatic collagen is a highly promising biomaterial for tissue engineering and regenerative medicine.
• Its favorable properties, cost-effectiveness, and sustainability address limitations of mammalian collagen.
• Further research and development are needed to overcome challenges and fully realize its potential.