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Changes in Coagulation in Cancer Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal
Mikkel Lundbech1,2, Matilde Damsbo1,2, Andreas Engel Krag2,3
1Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Seminars in Thrombosis and Hemostasis
|February 24, 2023
Summary
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) can affect blood clotting. This review found decreased platelet counts and altered secondary hemostasis markers within 10 days post-surgery.
Area of Science:
- Oncology
- Hematology
- Surgical Research
Background:
- Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex procedure associated with risks like venous thromboembolism and bleeding.
- Understanding the impact of HIPEC on hemostasis is crucial for managing postoperative complications.
Conclusions:
- Cytoreductive surgery with HIPEC leads to decreased platelet counts and subtle alterations in secondary hemostasis.
- Current data on the impact on fibrinolysis are limited and require further investigation.
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