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Related Experiment Video

Updated: Aug 9, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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Intra- and inter-hemispheric network dynamics supporting object recognition and speech production.

Yu Kitazawa1, Masaki Sonoda2, Kazuki Sakakura3

  • 1Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, 48201, USA; Department of Neurology and Stroke Medicine, Yokohama City University, Yokohama, 2360004, Japan.

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|February 24, 2023
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Summary

We mapped brain connectivity dynamics during object recognition and speech production using electrocorticography. These brain atlases reveal millisecond-scale white matter pathways crucial for these cognitive functions.

Keywords:
Event-related high-gamma synchronizationFunctional language mappingNormative dynamic tractography atlaspediatric epilepsy surgerysubdural electrocorticography (ECoG)

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Understanding the neural basis of object recognition and speech production is crucial for cognitive neuroscience.
  • Existing brain models often lack millisecond-scale temporal resolution of white matter connectivity dynamics.

Purpose of the Study:

  • To construct normative brain atlases detailing intra- and inter-hemispheric white matter connectivity dynamics.
  • To visualize functional connectivity modulations supporting object recognition and speech production at high temporal resolution.

Main Methods:

  • Quantified electrocorticographic (ECoG) high-gamma activity from 1,114 intracranial electrodes during naming tasks.
  • Utilized diffusion-weighted imaging tractography to identify direct white matter streamlines between electrode sites.
  • Defined functional connectivity as simultaneous, naming-related high-gamma modulations at connected sites.

Main Results:

  • Identified immediate, modality-specific connectivity enhancements post-stimulus onset.
  • Observed posterior-to-anterior propagation of left intra-hemispheric connectivity during response preparation.
  • Detailed task-specific connectivity patterns for picture naming, environmental sound naming, and auditory descriptive naming.
  • Highlighted common network enhancements for perceptual processing, semantic/lexical access, and overt speech.

Conclusions:

  • The developed brain atlases provide millisecond-scale insights into white matter connectivity supporting object recognition and speech production.
  • These findings enhance current models by incorporating dynamic neural pathways.
  • The study elucidates the role of both intra- and inter-hemispheric connectivity in complex cognitive functions.