[Lymphocytic "…itis", from esophagus to large bowel]

Area of Science:

• Gastroenterology and Pathology
• Histopathology
• Digestive Diseases

Background:

• Intra-epithelial lymphocytosis is a histological finding present throughout the gastrointestinal tract.
• Numerous conditions, including immune disorders, infections, and drug reactions, are linked to this lesion.
• Accurate etiological diagnosis necessitates correlating clinical information with pathological findings.

Approach:

• This review synthesizes current knowledge on digestive intra-epithelial lymphocytosis.
• It focuses on identifying associated pathological entities and diagnostic criteria.
• The goal is to aid pathologists in orienting diagnoses and selecting appropriate treatments.

Key Points:

• Intra-epithelial lymphocytosis is a versatile lesion found from the esophagus to the colon.
• Diagnosis hinges on anatomo-clinical correlation to uncover underlying causes.
• Histological examination for associated lesions is crucial for etiological diagnosis.

Conclusions:

• Understanding the differential diagnosis of intra-epithelial lymphocytosis is essential for effective patient management.
• This review provides a framework for diagnosing conditions associated with this common gastrointestinal finding.
• Accurate histological interpretation guides targeted therapeutic strategies.