Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution of the complication profile of AF ablation in the pulsed field era.

Journal of cardiology·2026
Same author

Pulsed Field Ablation Versus Sham to Treat Atrial Fibrillation: The PFA-SHAM Randomized Clinical Trial.

Circulation·2026
Same author

Diagnostic dilemma in the leadless era: Pacemaker failure or effective communication?

Heart rhythm·2026
Same author

High-Voltage Nanosecond Pulse Field Ablation Using a Compliant Circular Catheter to Treat Atrial Fibrillation: Lesion Durability and One-Year Outcomes.

JACC. Clinical electrophysiology·2026
Same author

Maximizing Lesion Depth With the Lattice-Tip Catheter: A Preclinical Comparison of Single, Double, and Mixed Pulsed-Field and Radiofrequency Applications.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Visually Guided Pulsed Field Ablation for Durable Pulmonary Vein Isolation Chronic Remapping and Clinical Outcomes in the First-in-Human VISION AF Study.

JACC. Clinical electrophysiology·2026

Related Experiment Video

Updated: Aug 9, 2025

Robotic Ablation of Atrial Fibrillation
11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

19.7K

PV Isolation Using a Spherical Array PFA Catheter: Application Repetition and Lesion Durability (PULSE-EU Study).

Mohit K Turagam1, Petr Neuzil2, Jan Petru2

  • 1Icahn School of Medicine at Mount Sinai, New York, New York, USA.

JACC. Clinical Electrophysiology
|February 24, 2023
PubMed
Summary

Repetitive pulsed field applications for pulmonary vein isolation (PVI) significantly improve PVI durability compared to single applications. This study shows repetitive pulsed field ablation (PFA) is key for consolidating lesions and maximizing PVI success.

Keywords:
atrial fibrillationcatheter ablationpulmonary vein isolationpulse field ablation

More Related Videos

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.4K
Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins
06:48

Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins

Published on: October 28, 2020

2.8K

Related Experiment Videos

Last Updated: Aug 9, 2025

Robotic Ablation of Atrial Fibrillation
11:21

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

19.7K
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.4K
Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins
06:48

Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins

Published on: October 28, 2020

2.8K

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Pulsed field ablation (PFA) shows increased lesion size with repeated applications.
  • Pulmonary vein isolation (PVI) is a common procedure for atrial fibrillation.

Purpose of the Study:

  • To determine if PVI durability differs between single and repetitive pulsed field (PF) applications.
  • To evaluate the safety and efficacy of a novel PFA catheter for PVI.

Main Methods:

  • 21 patients underwent PVI using a spherical multielectrode array PFA catheter.
  • Patients were divided into two groups: single PF application per pulmonary vein (PV) or three PF applications per PV.
  • Intracardiac echocardiography, esophagogastroduodenoscopy, brain MRI, and invasive remapping were performed.

Main Results:

  • PVI was acutely successful in 100% of patients in both groups.
  • Repetitive PF applications (Group 2) resulted in significantly higher durable PVI rates (100%) compared to single applications (Group 1, 62.5%).
  • No major adverse events like stroke or esophageal injury were reported.

Conclusions:

  • Repetitive PF applications enhance lesion consolidation and improve PVI durability.
  • The "single-shot" spherical array PFA catheter is safe and effective for PVI.
  • Optimizing PF application strategy is crucial for maximizing PVI success rates.