Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

5.7K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial versus global METRNL reveals importance of endothelial METRNL against atherosclerosis via mitochondrial homeostasis.

Pharmacological research·2026
Same author

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice.

CNS neuroscience & therapeutics·2026
Same author

Technologies and applications of current human cardiac organoids.

Acta pharmaceutica Sinica. B·2025
Same author

Cardiac Development, Cellular Composition and Function: From Regulatory Mechanisms to Applications.

Cells·2025
Same author

The hMetrnl-PLGA-PEG-PLGA Hydrogel Facilitates Skin Wound Healing Through Dual Regulation on eNOS Activity and Stability.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Construction of a Novel Secreted Protein Database and Identification of a New Adipokine CRELD2.

Diabetes & metabolism journal·2025
Same journal

Targeting BCL9/BCL9L enhances CD4<sup>+</sup> T cell-mediated Th1 antitumor immunity through activation of STAT1/STAT4 signaling.

Acta pharmacologica Sinica·2026
Same journal

TGF-β2 signaling promotes cardiac fibrosis in arrhythmogenic right ventricular cardiomyopathy mediated by DSC2 deficiency.

Acta pharmacologica Sinica·2026
Same journal

Correction: Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy.

Acta pharmacologica Sinica·2026
Same journal

Endothelial PARP1 orchestrates endothelial-to-mesenchymal transition via the PARylation of FHL2 in ischaemic heart failure.

Acta pharmacologica Sinica·2026
Same journal

Correction: Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling.

Acta pharmacologica Sinica·2026
Same journal

Adenosine receptor signaling in vascular diseases: from molecular mechanisms to targeted therapeutics.

Acta pharmacologica Sinica·2026
See all related articles

Related Experiment Video

Updated: Aug 9, 2025

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

2.8K

Angiogenesis after ischemic stroke.

Jie Fang1, Zhi Wang1, Chao-Yu Miao2

  • 1Department of Pharmacology, Second Military Medical University / Naval Medical University, Shanghai, 200433, China.

Acta Pharmacologica Sinica
|February 24, 2023
PubMed
Summary
This summary is machine-generated.

Stroke treatment remains limited, but promoting angiogenesis, the growth of new blood vessels, offers a promising therapeutic strategy for neural regeneration and functional recovery after ischemic stroke.

Keywords:
angiogenesisendothelial progenitor cellsischemic strokesecreted proteinsstem cells

More Related Videos

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

14.5K
Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

5.2K

Related Experiment Videos

Last Updated: Aug 9, 2025

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

2.8K
Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

14.5K
Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

5.2K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Stroke is a leading cause of death and disability globally, with limited treatment options beyond tissue plasminogen activator (tPA).
  • The underlying pathological mechanisms of stroke are not fully understood, highlighting the need for novel therapeutic approaches.
  • Angiogenesis plays a crucial role in neural regeneration and functional recovery following stroke.

Purpose of the Study:

  • To review cellular and molecular mechanisms influencing angiogenesis after cerebral ischemia.
  • To explore pro-angiogenic strategies for treating ischemic stroke.

Main Methods:

  • Literature search of PubMed for studies on angiogenesis after cerebral ischemia.
  • Synthesis of information on cellular and molecular mechanisms.
  • Identification and summarization of pro-angiogenic therapeutic strategies.

Main Results:

  • Identified key cellular and molecular factors regulating angiogenesis post-stroke.
  • Highlighted various pro-angiogenic approaches including stem cells, growth factors, and non-coding RNAs.
  • Emphasized the potential of targeting angiogenesis for stroke recovery.

Conclusions:

  • Inducing angiogenesis in the peri-infarct area can improve hemodynamics and neurovascular function.
  • Pro-angiogenic strategies show promise for enhancing recovery from ischemic stroke.
  • Further research into these strategies may lead to improved clinical treatments for stroke.