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Tenascin C in Lung Diseases.

Chantal Donovan1,2, Xu Bai1,3, Yik Lung Chan1

  • 1School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.

Biology
|February 25, 2023
PubMed
Summary

Tenascin C (TNC) increases during lung development and in response to maternal particulate matter exposure. TNC is also elevated in asthma, COPD, and lung cancer, suggesting it as a potential therapeutic target for lung diseases.

Keywords:
COPDasthmafoetal programminglung cancerlung developmentparticular matter

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pulmonary Medicine

Background:

  • Tenascin C (TNC) is a large extracellular matrix protein with diverse roles in development and disease.
  • Its specific involvement in adult lung pathologies, including asthma, COPD, and lung cancer, is not well understood.

Purpose of the Study:

  • To investigate the expression patterns of Tenascin C (TNC) in various lung conditions.
  • To explore the role of TNC in lung development, maternal particulate matter exposure effects, asthma, COPD, and lung cancer.

Main Methods:

  • Analysis of TNC expression during lung development.
  • Assessment of TNC and collagen in offspring following maternal particulate matter exposure.
  • Evaluation of TNC expression in lung tissues from patients with asthma, COPD, and lung cancer.

Main Results:

  • TNC expression was upregulated during normal lung development across multiple cell types.
  • Maternal particulate matter exposure led to increased TNC and collagen deposition, persisting post-exposure.
  • Elevated TNC levels were observed in basal epithelial cells and fibroblasts in asthma, and AT2 and endothelial cells in COPD.
  • TNC expression increased from stage IA to stage II lung cancer, but did not correlate with patient survival.

Conclusions:

  • Tenascin C (TNC) expression is significantly increased during lung development and in response to environmental insults like particulate matter.
  • TNC is upregulated in major lung diseases including asthma, COPD, and lung cancer.
  • Targeting Tenascin C (TNC) presents a potential novel therapeutic strategy for managing lung diseases.