Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.8K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.1K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

13.3K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
13.3K
Protein Networks02:26

Protein Networks

4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

6.9K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models.

Biology·2024
Same author

Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer's disease.

Aging cell·2021
Same author

Oxidative damage of lysosomes in regulated cell death systems: Pathophysiology and pharmacologic interventions.

Free radical biology & medicine·2020
Same author

Inhibition of VDAC1 Protects Against Glutamate-Induced Oxytosis and Mitochondrial Fragmentation in Hippocampal HT22 Cells.

Cellular and molecular neurobiology·2018
Same author

Preconditioned neurons with NaB and nicorandil, a favorable source for stroke cell therapy.

Journal of cellular biochemistry·2018
Same author

Environmental Stimulus on Stem Cell Behaviour.

Stem cells international·2018

Related Experiment Video

Updated: Aug 9, 2025

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

9.0K

Tau; One Protein, So Many Diseases.

Parisa Tabeshmehr1, Eftekhar Eftekharpour1

  • 1Spinal Cord Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

Biology
|February 25, 2023
PubMed
Summary

This review explores tau protein

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Tau protein, a microtubule-associated protein, is crucial for neuronal cytoskeleton structure and function.
  • Pathologic tau aggregates form neurofibrillary tangles, leading to a spectrum of diseases known as tauopathies.
  • Tauopathies exhibit significant heterogeneity in tau isoforms, affected cell types, and brain regions, complicating diagnosis and treatment.

Purpose of the Study:

  • To review recent literature on tau protein and the pathophysiological mechanisms of tauopathies.
  • To summarize upstream and downstream events in tau pathology.
  • To discuss current diagnostic and therapeutic strategies for tauopathies.

Main Methods:

  • Literature review of recent scientific publications on tau protein and tauopathies.
Keywords:
Alzheimer’s diseaseMAPTagingcytoskeletondementianeurodegenerationtautauopathy

More Related Videos

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.4K
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

18.5K

Related Experiment Videos

Last Updated: Aug 9, 2025

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

9.0K
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.4K
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

18.5K
  • Analysis of pathophysiological mechanisms, including tau aggregation and isoform involvement.
  • Synthesis of information on diagnostic approaches and therapeutic interventions.

    • Main Results:

    • Tau protein has diverse functions beyond cytoskeletal support, with its aggregation driving neurodegeneration.
    • Twenty-six distinct tauopathies exist, characterized by specific tau aggregates and affected brain areas.
    • Disease heterogeneity presents challenges for developing effective diagnostic and therapeutic strategies.

    Conclusions:

    • Understanding tau protein's dual role (physiological and pathological) is key to addressing tauopathies.
    • Further research into upstream/downstream events and disease heterogeneity is crucial for advancing diagnostics and therapeutics.
    • Targeting tau pathology offers potential for treating a range of neurodegenerative disorders.