In-Silico and In-Vitro Analysis of the Novel Hybrid Comprehensive Stage II Operation for Single Ventricle Circulation

Area of Science:

• Cardiology
• Biomedical Engineering
• Medical Physics

Background:

• Single ventricle (SV) anomalies are a significant cause of congenital heart disease, with current palliative treatments having a 50% survival rate.
• The hybrid comprehensive stage II (HCSII) operation was developed to improve outcomes for select SV patients, aiming to reduce surgical trauma.

Purpose of the Study:

• To investigate the hemodynamics of patients undergoing the HCSII operation.
• To validate computational fluid dynamics (CFD) and mock flow loop (MFL) models against patient-specific data.

Main Methods:

• Development of a multiscale CFD model and an MFL model for HCSII patients.
• Tuning of both models using patient-specific hemodynamic data from catheterization.
• Correlation analysis between clinical data and in-vitro/in-silico measurements.

Main Results:

• Hemodynamic findings from clinical data showed a strong correlation (r = 0.9) with in-vitro and in-silico measurements.
• Geometrical modifications in the models had minimal impact on oxygen delivery.
• Particle residence time studies indicated efficient ejection within one cardiac cycle, with no pathological flow patterns observed.

Conclusions:

• The study validates the hemodynamic safety and efficacy of the HCSII operation for select single ventricle patients.
• CFD and MFL modeling are reliable tools for assessing hemodynamics in complex congenital heart disease interventions.