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Polymeric Materials, Advances and Applications in Tissue Engineering: A Review
María Cecilia Socci1,2, Gabriela Rodríguez1,2, Emilia Oliva1,2
1Laboratorio de Medios e Interfases (LAMEIN), Departamento de Bioingeniería, FACET-UNT, Tucumán 4000, Argentina.
Bioengineering (Basel, Switzerland)
|February 25, 2023
Summary
Tissue Engineering (TE) utilizes advanced biomaterials and scaffolds to regenerate tissues and organs. This review covers TE principles, polymeric scaffolds, and applications, highlighting current progress and future challenges in regenerative medicine.
Area of Science:
- Interdisciplinary field combining materials science, biology, and engineering.
- Focus on regenerative medicine and therapeutic strategies for tissue and organ restoration.
Background:
- Increasing demand for improved quality of life necessitates innovative regenerative medicine approaches.
- Polymeric porous scaffolds are crucial for tissue restoration, cell interaction, and inducing regeneration.
Purpose of the Study:
- To review polymeric scaffold materials and production techniques in Tissue Engineering (TE).
- To explore basic TE principles and current strategies in eight key application areas.
- To identify obstacles and future research needs for clinical translation of TE implants.
Main Methods:
- Comprehensive review of polymeric scaffold materials and fabrication methods.
- Analysis of current TE strategies across epithelial, bone, uterine, vascular, nerve, cartilaginous, cardiac, and urinary tissues.
- Examination of clinically approved polymer-based medical devices and commercial biomaterials.
Main Results:
- Detailed overview of various polymeric scaffolds and their production techniques.
- Illustrative examples of TE strategies in eight distinct tissue regeneration applications.
- Identification of available polymer-based medical devices and biomaterials.
Conclusions:
- Significant advancements exist in TE, with numerous polymeric biomaterials available.
- Clinical translation of TE implants faces challenges, requiring further research and development.
- Regenerative medicine holds promise but needs continued innovation to overcome existing hurdles.
