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Published on: August 30, 2018
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Electrolyte Disorders Associated with Piperacillin/Tazobactam: A Pharmacovigilance Study Using the FAERS Database.
Heenam Seo1,2, Eunyoung Kim2,3,4
1Department of Pharmacy, Kangbuk Samsung Hospital, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of Korea.
Antibiotics (Basel, Switzerland)
|February 25, 2023
Summary
Piperacillin-tazobactam (TZP), a common antibiotic, is significantly linked to hypokalemia, a dangerous electrolyte disorder. This finding highlights a potential risk associated with TZP use in patients.
Area of Science:
- Pharmacovigilance
- Clinical Pharmacology
- Internal Medicine
Background:
- Electrolyte disorders (EDs) pose significant health risks.
- Piperacillin-tazobactam (TZP) is a frequently prescribed antibiotic for serious infections.
Purpose of the Study:
- To investigate the potential association between piperacillin-tazobactam (TZP) and electrolyte imbalances.
- To identify specific electrolyte disorders linked to TZP use.
Main Methods:
- A disproportionality analysis was performed on the US FDA Adverse Event Reporting System (FAERS) database from 2004 to 2018.
- Data mining indices including PRR, ROR, and IC were calculated to detect adverse event signals for TZP.
- Further analyses compared TZP to other penicillins.
Main Results:
- A total of 9829 reports related to TZP were analyzed.
- Hypokalemia was identified as the only significant electrolyte disorder signal associated with TZP compared to all other drugs.
- Hypokalemia remained a significant signal for TZP when compared to other penicillins.
Conclusions:
- Piperacillin-tazobactam (TZP) is significantly associated with the development of hypokalemia.
- This association warrants clinical consideration, especially in patients at risk for electrolyte disturbances.
Keywords:
FAERS databasedata miningdisproportionality analysiselectrolyte disorderhypokalemiapenicillinspharmacovigilancepiperacillin/tazobactamMore Related Videos
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