Related Experiment Video

Updated: Aug 9, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: August 30, 2018

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Electrolyte Disorders Associated with Piperacillin/Tazobactam: A Pharmacovigilance Study Using the FAERS Database

Heenam Seo1,2, Eunyoung Kim2,3,4

  • 1Department of Pharmacy, Kangbuk Samsung Hospital, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of Korea.

Antibiotics (Basel, Switzerland)
|February 25, 2023
PubMed

Insights

Piperacillin-tazobactam (TZP), a common antibiotic, is significantly linked to hypokalemia, a dangerous electrolyte disorder. This finding highlights a potential risk associated with TZP use in patients.

Area of Science:

  • Pharmacovigilance
  • Clinical Pharmacology
  • Internal Medicine

Background:

  • Electrolyte disorders (EDs) pose significant health risks.
  • Piperacillin-tazobactam (TZP) is a frequently prescribed antibiotic for serious infections.

Purpose of the Study:

  • To investigate the potential association between piperacillin-tazobactam (TZP) and electrolyte imbalances.
  • To identify specific electrolyte disorders linked to TZP use.

Main Methods:

  • A disproportionality analysis was performed on the US FDA Adverse Event Reporting System (FAERS) database from 2004 to 2018.
  • Data mining indices including PRR, ROR, and IC were calculated to detect adverse event signals for TZP.
  • Further analyses compared TZP to other penicillins.

Main Results:

  • A total of 9829 reports related to TZP were analyzed.
  • Hypokalemia was identified as the only significant electrolyte disorder signal associated with TZP compared to all other drugs.
  • Hypokalemia remained a significant signal for TZP when compared to other penicillins.

Conclusions:

  • Piperacillin-tazobactam (TZP) is significantly associated with the development of hypokalemia.
  • This association warrants clinical consideration, especially in patients at risk for electrolyte disturbances.
Keywords:
FAERS databasedata miningdisproportionality analysiselectrolyte disorderhypokalemiapenicillinspharmacovigilancepiperacillin/tazobactam

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