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Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
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An Insight on Functioning Pancreatic Neuroendocrine Neoplasms
Michele Bevere1,2, Anastasios Gkountakos1,2, Filippo Maria Martelli1
1Department of Diagnostics and Public Health, Section of Anatomical Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
Biomedicines
|February 25, 2023
Summary
Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors. This review explores functioning PanNENs, highlighting diagnostic, molecular, and therapeutic advances for better patient outcomes.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Pancreatic neuroendocrine neoplasms (PanNENs) are rare pancreatic tumors originating from islet cells.
- They are classified as functioning (hormone-secreting) or nonfunctioning, with functioning types further divided into specific subgroups based on hormone production.
Purpose of the Study:
- To review the current understanding of functioning PanNENs, focusing on diagnosis, molecular profiling, and treatment.
- To highlight the need for better characterization of functioning PanNEN subgroups using advanced technologies.
Main Methods:
- This narrative review synthesizes current literature on PanNENs.
- It discusses advancements in high-throughput techniques and diagnostic tools for molecular characterization.
Main Results:
- Surgery is the only curative treatment for PanNENs.
- High-throughput techniques have improved molecular knowledge, revealing potential therapeutic vulnerabilities.
- Significant knowledge gaps persist regarding specific functioning PanNEN subgroups.
Conclusions:
- Combining high-throughput platforms with novel diagnostic tools is crucial for differentiating functioning PanNEN subgroups.
- Further research is needed to improve diagnosis, molecular understanding, and treatment strategies for all PanNEN subtypes.
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